© 2015, Springer-Verlag Berlin Heidelberg.Genetic studies have identified single nucleotide polymorphisms associated with the risk of prostate cancer. It remains unclear whether such genetic variants are associated with disease aggressiveness. The NCI-SPORE Genetics Working Group retrospectively collected clinicopathologic information and genotype data for 36 SNPs which at the time had been validated to be associated with PC risk from 25,674 cases with PC. Cases were grouped according to race, Gleason score and aggressiveness. Statistical analyses were used to compare the frequency (...) of the SNPs between different disease cohorts. After adjusting for multiple testing, only PC-risk SNP rs2735839 was significantly and inversely associated with aggressive and high-grade disease in European men. Similar associations with aggressive and high-grade disease were documented in African-American subjects. The G allele of rs2735839 was associated with disease aggressiveness even at low PSA levels in both European and African-American men. Our results provide further support that a PC-risk SNP rs2735839 near the KLK3 gene on chromosome 19q13 may be associated with aggressive and high-grade PC. Future prospectively designed, case-case GWAS are needed to identify additional SNPs associated with PC aggressiveness. (shrink)

Chance both guides our credences and is an objective feature of the world. How and why we should conform our credences to chance depends on the underlying metaphysical account of what chance is. I use considerations of accuracy (how close your credences come to truth-values) to propose a new way of deferring to chance. The principle I endorse, called the Trust Principle, requires chance to be a good guide to the world, permits modest chances, tells us how to listen to (...) chance even when the chances are modest, and entails but is not entailed by the New Principle. As I show, a rational agent will obey this principle if and only if she expects chance to be at least as accurate as she is on every good way of measuring accuracy. Much of the discussion, and the technical results, extend beyond chance to deference to any kind of expert. Indeed, you will trust someone about a particular question just in case you expect that person to be more accurate than you are about that question. (shrink)

In Plato's Lysis, Socrates' conversation with Lysis features logical fallacies and questionable premises and closes with a blatantly eristic trick. I show how the form and content of these arguments make sense if we interpret them from the perspective of Socrates' pedagogical goals. Lysis is a competitive teenager who, along with his friend Menexenus, enjoys the game of eristic disputation. Socrates recognizes Lysis' predilections, and he constructs his arguments to engage Lysis' interests and loves, while also drawing the boy into (...) thinking philosophically about the issues that the arguments raise about love, freedom, and happiness. (shrink)

ABSTRACTMany texts in the Epicurean tradition mention gratitude but do not explicitly explain its function in Epicurean ethics. I review passages that mention or discuss gratitude and ingratitude a...

While stakeholder theory has traditionally considered organization’s interactions with stakeholders in terms of independent, dyadic relationships, recent scholarship has pointed to the fact that organizations exist within a complex network of intertwining relationships [e.g., Rowley, T. J.: 1997, The Academy of Management Review 22(4), 887–910]. However, further theoretical and empirical development of the interactions between stakeholders has been lacking. In this paper, we develop a framework for understanding and measuring the effects upon the organization of competing, complementary and cooperative stakeholder (...) interactions, which we refer to as stakeholder multiplicity. We draw upon three forms of fit (i.e. fit as matching, fit as moderation, and fit as gestalts; Venkatraman, N.: 1989) to develop a framework for understanding stakeholder multiplicity based upon the direction, strength, and synergies of the interacting claims. Additionally, we draw upon the theory of stakeholder identification and salience of Mitchell et al. (1997), which we argue provides a more relevant and significantly more illustrative explanation of the nature and effects of stakeholder interactions upon the organization than the network approach of Rowley (1997). Furthermore, we ground our framework through reference to three stakeholder groups (i.e. governments, customers, and employees) and the stakeholder issue of concern for the natural environment. We propose a hierarchy of the multiplicity strength of influence of these three stakeholder groups. Potential measurement and implications are discussed. (shrink)

Evidential Decision Theory and Causal Decision Theory are the leading contenders as theories of rational action, but both face counterexamples. We present some new counterexamples, including one in which the optimal action is causally dominated. We also present a novel decision theory, Functional Decision Theory, which simultaneously solves both sets of counterexamples. Instead of considering which physical action of theirs would give rise to the best outcomes, FDT agents consider which output of their decision function would give rise to the (...) best outcome. This theory relies on a notion of subjunctive dependence, where multiple implementations of the same mathematical function are considered to have identical results for logical rather than causal reasons. Taking these subjunctive dependencies into account allows FDT agents to outperform CDT and EDT agents in, for example, the presence of accurate predictors. (shrink)

The present study investigated how the magnitude the word blindness suggestion effect on Stroop interference depended on hypnotic suggestibility when given as an imaginative suggestion and under conditions in which hypnosis was not mentioned. Hypnotic suggestibility is shown to be a significant predictor of the magnitude of the imaginative word blindness suggestion effect under these conditions. This is therefore the first study to show a linear relationship between the imaginative word blindness suggestion effect and hypnotic suggestibility across the whole hypnotizability (...) spectrum. The results replicate previous findings showing that highs respond to the word blindness suggestion to a greater extent than lows but extend previous work by showing that the advantage for those higher on the hypnotizability spectrum occurs even in a non-hypnotic context. Negative attitudes about hypnosis may not explain the failure to observe similar effects of the word blindness suggestion in less hypnotizable individuals. (shrink)

Some propositions are more epistemically important than others. Further, how important a proposition is is often a contingent matter—some propositions count more in some worlds than in others. Epistemic Utility Theory cannot accommodate this fact, at least not in any standard way. For EUT to be successful, legitimate measures of epistemic utility must be proper, i.e., every probability function must assign itself maximum expected utility. Once we vary the importance of propositions across worlds, however, normal measures of epistemic utility become (...) improper. I argue there isn’t any good way out for EUT. (shrink)

These essays collectively present new perspectives on the history of modern science in China since 1900. Fa‐ti Fan describes how science under the Republic of China after 1911 exhibited a complex local and international character that straddled both imperialism and colonialism. Danian Hu focuses on the fate of relativity in the physics community in China after 1917. Zuoyue Wang hopes that a less nationalist political atmosphere in China will stimulate more transnational studies of modern science, which will in turn reveal (...) the underlying commonalities in different national contexts. Sigrid Schmalzer compares the socialist and the capitalist contexts for science in China and reopens the sensitive question of the “mass line” during the Cultural Revolution. Grace Shen describes the tensions early Chinese scientists felt when choosing between foreign models for modern geology and their own professional identities in China. Taken together, these accounts present us with a comparative history of modern science in China that is both globally and locally informed. (shrink)

In recent years, Plato’s Lysis has received much attention from professional scholars, but could it be used as a text in introductory classes? It is true that the Lysis poses challenges as an introductory text—its arguments are fast-paced and abstract. But I argue that the Lysis is actually an excellent pedagogical text, well suited to engage novices and introduce them to philosophy’s distinctive methods and way of thinking. It works particularly well as a text for engaging students in active learning, (...) insofar as it opens up a space for improvisation and exploration, providing tools for the readers and inviting them to take an active role in constructing their own understandings. (shrink)

© 2020, Edizioni ETS. All rights reserved. This lecture outlines elements central to the project of rethinking the concerns of political theology. The lecture seeks to integrate that thinking into the development of a philosophy of life; life defined by an already given relation to the law. Maintaining the law, which is the stance against nihilism, whilst complicating the way law is understood, involves a shift in how sovereignty would itself then be conceived.

We consider the questions of whether or not large language models (LLMs) have beliefs, and, if they do, how we might measure them. First, we consider whether or not we should expect LLMs to have something like beliefs in the first place. We consider some recent arguments aiming to show that LLMs cannot have beliefs. We show that these arguments are misguided. We provide a more productive framing of questions surrounding the status of beliefs in LLMs, and highlight the empirical (...) nature of the problem. With this lesson in hand, we evaluate two existing approaches for measuring the beliefs of LLMs, one due to Azaria and Mitchell (The internal state of an llm knows when its lying, 2023) and the other to Burns et al. (Discovering latent knowledge in language models without supervision, 2022). Moving from the armchair to the desk chair, we provide empirical results that show that these methods fail to generalize in very basic ways. We then argue that, even if LLMs have beliefs, these methods are unlikely to be successful for conceptual reasons. Thus, there is still no lie-detector for LLMs. We conclude by suggesting some concrete paths for future work. (shrink)

In the Alcibiades I, Socrates argues for the importance of self-knowledge. Recent interpreters contend that the self-knowledge at issue here is knowledge of an impersonal and purely rational self. I argue against this interpretation and advance an alternative. First, the passages proponents of this interpretation cite—Socrates’ argument that the self is the soul, and his suggestion that Alcibiades seek self-knowledge by looking for his soul’s reflection in the soul of another—do not unambiguously support their reading. Moreover, other passages, particularly Socrates’ (...) cross-examination of Alcibiades, suggest the contrary reading, that self-knowledge includes knowledge of qualities peculiar to the individual. (shrink)

Is a devoted Nazi or a zombie bureaucrat a greater moral and political problem? Because the dangers of immoral fanaticism are so clear, the dangers of mindless bureaucracy are easy to overlook. Yet zombie bureaucrats have contributed substantially to the greatest catastrophes of the 20th century, doing so seemingly oblivious to the monstrous qualities of their actions. Hannah Arendt’s work on thoughtlessness raises a dilemma: if Eichmann, the architect of the Nazi Final Solution, truly was a thoughtless ‘cog’, lacking in (...) intentionality, can one really hold him morally accountable for the evil qualities of his acts? This article relates Arendt’s ‘thought’ and Strawson’s and Bilgrami’s discussion of ‘reactive attitudes’ and Sartre’s concept of ‘bad faith’. To find a basis for moral accountable in seemingly thoughtless cases like Eichmann’s. Although Arendt’s Eichmann is an extreme example, finding a basis to hold him accountable is valuable because ‘little Eichmanns’ will persist as long as impersonal forces structure and depress reactive attitudes. (shrink)

There are many things—call them ‘experts’—that you should defer to in forming your opinions. The trouble is, many experts are modest: they’re less than certain that they are worthy of deference. When this happens, the standard theories of deference break down: the most popular (“Reflection”-style) principles collapse to inconsistency, while their most popular (“New-Reflection”-style) variants allow you to defer to someone while regarding them as an anti-expert. We propose a middle way: deferring to someone involves preferring to make any decision (...) using their opinions instead of your own. In a slogan, deferring opinions is deferring decisions. Generalizing the proposal of Dorst (2020a), we first formulate a new principle that shows exactly how your opinions must relate to an expert’s for this to be so. We then build off the results of Levinstein (2019) and Campbell-Moore (2020) to show that this principle is also equivalent to the constraint that you must always expect the expert’s estimates to be more accurate than your own. Finally, we characterize the conditions an expert’s opinions must meet to be worthy of deference in this sense, showing how they sit naturally between the too-strong constraints of Reflection and the too-weak constraints of New Reflection. (shrink)

In this paper I hope to show that Geach misunderstands the nature of Plato's argument in the Euthyphro and more importantly the reasoning behind the dialectical strategy adopted by Socrates. Furthermore I shall argue that Geach's reading of the Euthyphro engenders serious difficulties, that stand in the way of understanding the manner in which Plato construes the problem of determining the nature of, and relationship between universal and particulars, which is of great significance because it is precisely this problem, in (...) relation to piety, that is central to the Euthyphro. In the appendix I shall sketch the outline of an argument in order to justify the assumption that the theory of Forms is present in the Euthyphro. (shrink)

Avicenna and the Aristotelian Left is the first English rendition of Ernst Bloch's thought-provoking monograph dedicated to the thought of Ibn Sīnā, the prominent eleventh-century Persian polymath. Published in 2019 by Columbia University Press as part of the New Directions in Critical Theory series, it joins a growing list of translations that goes back to the 1966 Spanish version by Jorge Deike Robles and, more recently, to Claude Maillard's and Nicola Allesandrini's French and Italian renditions, respectively. This new English edition (...) is based on Bloch's final version of the essay--a revised version of the original 1952 text, later incorporated as an... (shrink)

Mild and moderate mental illnesses can hinder labor force participation, lead to work interruptions, and hamper earning potential. Targeted interventions have proven effective at addressing these problems. But their potential depends on labor protections that enable people to take advantage of these interventions while keeping jobs and income.

Abstract:Designers whose projects are inspired by a community’s unique sense of spatial identity often focus on a site’s observable context, i.e. historic forms and surface aesthetics. Focus on typological components, however, overlooks generative relationships between the phenomenology of place and human energy investment. Recognizing Kubler’s dictum that material history is an observable continuum then, at its most fundamental level, the history of spatial production is the history of energy use. For most of human history, place was a unique socio-cultural expression (...) because it fused energy expenditure with site-specific conditions, including climate, topography and materials. This paper introduces the concept of burden distance, the distance needed to travel to material sources and bring them back from origin points to their place of use. This proposed concept parallels Walter Christaller’s Central Place Theory idea of “range,” but applied in terms phenomenological implications of energy investment and placemaking. Understanding burden distance and its role in placemaking, is an important step in identifying why built environments have a spatial specificity that contributes to mitigate spatial alienation and instead root people to their built environment. (shrink)

Este trabajo examina el parecer del obispo y humanista Juan Bautista Pérez , uno de los primeros críticos de las reliquias desenterradas en Granada a partir de 1588. Dada su política morisca bastante progresista en la diócesis de Segorbe, bien habría podido Pérez aprobar la aparición de los plomos, que creaban una historia común para cristianos y musulmanes. Su erudición, por el contrario, le hizo concluir que los plomos fueron una fabricación moderna, y que su veneración pondría en peligro de (...) desviación religiosa al pueblo español. El parecer de Pérez es un ejemplo de rigor, creatividad, y devoción religiosa entre los humanistas de finales del siglo XVI. (shrink)

Este trabajo analiza cómo cinco libros de texto españoles usados en 2º de la ESO tratan el tema de Colón y su interacción con las poblaciones indígenas de América. Hasta ahora, las investigaciones realizadas se centraban en la evolución diacrónica del discurso seguido en los libros de texto o comparaban los ejemplares usados en diferentes países. Con frecuencia, los investigadores han dado por hecho (a veces implícitamente) que el discurso “oficial” que rige el conjunto de libros de texto de una (...) nación es más o menos homogéneo y, por tanto, puede ser sintetizado en una serie de trazos. Por el contrario, este trabajo subraya la existencia de diferencias significativas en el tratamiento que los textos españoles hacen del llamado “descubrimiento de América”. Así, y pese a los distintos acercamientos al tema, ninguno de los libros examinados satisface la necesaria minimización de la perspectiva eurocéntrica a la hora de explicar la historia de las Américas. (shrink)

Despite their ethical intentions, ethically minded consumers rarely purchase ethical products (Auger and Devinney: 2007, Journal of Business Ethics76, 361–383). This intentions–behaviour gap is important to researchers and industry, yet poorly understood (Belk et al.: 2005, Consumption, Markets and Culture8(3), 275–289). In order to push the understanding of ethical consumption forward, we draw on what is known about the intention–behaviour gap from the social psychology and consumer behaviour literatures and apply these insights to ethical consumerism. We bring together three separate (...) insights – implementation intentions (Gollwitzer: 1999, American Psychologist54(7), 493–503), actual behavioural control (ABC) (Ajzen and Madden: 1986, Journal of Experimental Social Psychology22, 453–474; Sheeran et al.: 2003, Journal of Social Psychology, 42, 393–410) and situational context (SC) (Belk: 1975, Journal of Consumer Research2, 157–164) – to construct an integrated, holistic conceptual model of the intention–behaviour gap of ethically minded consumers. This holistic conceptual model addresses significant limitations within the ethical consumerism literature, and moves the understanding of ethical consumer behaviour forward. Further, the operationalisation of this model offers insight and strategic direction for marketing managers attempting to bridge the intention–behaviour gap of the ethically minded consumer. (shrink)

What did it mean to keep a secret in early medieval England? It was a period during which the experience of secrecy was intensely bound to the belief that God knew all human secrets, yet the secrets of God remained unknowable to human beings. In Bonds of Secrecy, Benjamin A. Saltzman argues that this double-edged conception of secrecy and divinity profoundly affected the way believers acted and thought as subjects under the law, as the devout within monasteries, and as (...) readers before books. One crucial way it did so was by forming an ethical relationship between the self and the world that was fundamentally different from its modern reflex. Whereas today the bearers of secrets might be judged for the consequences of their reticence or disclosure, Saltzman observes, in the early Middle Ages a person attempting to conceal a secret was judged for believing he or she could conceal it from God. In other words, to attempt to hide from God was to become ensnared in a serious sin, but to hide from the world while deliberately and humbly submitting to God's constant observation was often a hallmark of spiritual virtue. Looking to law codes and religious architecture, hagiographies and riddles, Bonds of Secrecy shows how legal and monastic institutions harnessed the pervasive and complex belief in God's omniscience to produce an intense culture of scrutiny and a radical ethics of secrecy founded on the individual's belief that nothing could be hidden from God. According to Saltzman, this ethics of secrecy not only informed early medieval notions of mental activity and ideas about the mind but also profoundly shaped the practices of literary interpretation in ways that can inform our own contemporary approaches to reading texts from the past. (shrink)